Endocrine Abstracts

Glucocorticoid signalling is essential during embryonic lung development, with both the global and epithelial glucocorticoid receptor (GR) null mice presenting with lung atelectasis and post natal lethality. In this study, we examined the role of glucocorticoid signalling within mesenchymal tissues. To study the role of the GR in mesenchymal tissues during embryogenesis we crossed GRflox mice with Dermo1-Cre mice to generate GRDermo1 mice, where the GR gene was cond...